Quinolines as Chemotherapeutic Agents for Leishmaniasis

Quinolines as chemotherapeutic agents for leishmaniasis.

The development of leishmanicidal quinolines and their in vitro (promastigote and amastigote) and, where applicable, in vivo activities are reviewed. This survey provides a direct comparison of bioactivity across different species(e.g. L. donovani, L. amazonensis, L. chagasi, L infantum), and in different animal models (e.g. L. donovani Balb/c mice and L. donovani infected hamsters). The progre...

Enzymes as Chemotherapeutic Agents

Fullerenes as Agents for Chemotherapeutic Drug Delivery

In a world where the scale of technology is continuously shrinking, from phones to cars to solar panels, nanotechnology is seeing a rise in applications. Recently, increased use of nanotechnology in the medical industry brought fullerenes, sometimes referred to as Buckyballs, to the forefront. Fullerenes are currently being developed by engineers to encapsulate a chemotherapeutic drug and deliv...

Inhibition of glutathione synthesis as a chemotherapeutic strategy for leishmaniasis.

This study focuses on the use of buthionine sulphoximine (BSO), a gamma-glutamylcysteine synthetase inhibitor, on Leishmania donovani growth. The effect of BSO on amastigote multiplication within macrophages showed that 5 mM BSO decreased infectivity by about 50% and the mean number of amastigotes per 100 infected macrophages by 21%. The mechanism may be that BSO resulted in enhanced nitric oxi...

Metal Complexes as Drugs and Chemotherapeutic Agents

9.18.